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CHROMSYSTEMS

CHROMSYSTEMS

Chromsystems offers technologies for clinical analysis by HPLC and mass spectrometry to clinical laboratories that help provide reliable and accurate results for doctors and patients. It offers assays with a large parameter menu covering new born screening, therapeutic drug monitoring, steroid analysis, vitamin profilin ...
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About CHROMSYSTEMS

Chromsystems offers technologies for clinical analysis by HPLC and mass spectrometry to clinical laboratories that help provide reliable and accurate results for doctors and patients. It offers assays with a large parameter menu covering new born screening, therapeutic drug monitoring, steroid analysis, vitamin profiling and more.

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Malondialdehyde HPLC Test
Malondialdehyde in Serum/Plasma – HPLC

Chromsystems’ Malondialdehyde in Serum/Plasma – HPLC kit quantifies malondialdehyde (MDA), a biomarker of lipid peroxidation and oxidative stress. Used in evaluating patients with respiratory or degenerative conditions, it provides interference-free analysis for reliable results.
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Glutathione HPLC Test
Glutathione in Whole Blood – HPLC

The Glutathione in Whole Blood – HPLC kit measures both reduced (GSH) and oxidized (GSSG) glutathione in whole blood. It requires just 10 µL sample volume and uses internal standards for accuracy. Ideal for oxidative stress monitoring and liver function assessments.
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HPLC Vitamin C Test
Vitamin C in Plasma/Serum – HPLC

Chromsystems’ HPLC test enables precise quantification of Vitamin C in plasma or serum. Featuring enhanced column and sample stability, it helps assess nutritional status or deficiency-related conditions like scurvy or oxidative stress.
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Clinical Laboratory

Malondialdehyde HPLC Test
Malondialdehyde in Serum/Plasma – HPLC

Chromsystems’ Malondialdehyde in Serum/Plasma – HPLC kit quantifies malondialdehyde (MDA), a biomarker of lipid peroxidation and oxidative stress. Used in evaluating patients with respiratory or degenerative conditions, it provides interference-free analysis for reliable results.
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Glutathione HPLC Test
Glutathione in Whole Blood – HPLC

The Glutathione in Whole Blood – HPLC kit measures both reduced (GSH) and oxidized (GSSG) glutathione in whole blood. It requires just 10 µL sample volume and uses internal standards for accuracy. Ideal for oxidative stress monitoring and liver function assessments.
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HPLC Vitamin C Test
Vitamin C in Plasma/Serum – HPLC

Chromsystems’ HPLC test enables precise quantification of Vitamin C in plasma or serum. Featuring enhanced column and sample stability, it helps assess nutritional status or deficiency-related conditions like scurvy or oxidative stress.
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Urine Control
MassCheck Amino Acid Analysis Urine Controls

The MassCheck Amino Acid Analysis Urine Controls are designed to ensure the accuracy and reliability of amino acid quantification in urine samples via LC-MS/MS. Available in three distinct concentration levels, these lyophilized controls are based on a human matrix, providing a realistic standard for method validation and routine quality assurance. They are essential for laboratories engaged in metabolic disorder diagnostics, offering confidence in analytical results and aiding in the maintenance of stringent quality standards.
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Therapeutic Drug Monitoring System
MassTox TDM MasterColumn A

The MassTox TDM MasterColumn A is an innovative analytical column engineered for therapeutic drug monitoring (TDM) applications via LC-MS/MS. This versatile column is compatible with multiple parameter sets, eliminating the need for column switching and thereby streamlining the analytical process. It ensures high-resolution separation of a wide range of pharmaceutical substances, making it a valuable asset for laboratories focused on precise and efficient drug analysis.
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Cortisol & Cortisone Saliva Control
6PLUS1 Multilevel Saliva Calibrator Set

The 6PLUS1 Multilevel Saliva Calibrator Set is specifically designed for the accurate quantification of cortisol and cortisone levels in saliva samples using LC-MS/MS. This calibrator set comprises six distinct concentration levels, facilitating the creation of precise calibration curves essential for reliable hormone analysis. Utilizing a human-based matrix, these calibrators closely mimic actual patient samples, thereby enhancing the accuracy and traceability of results.
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β-Carotene Serum Control
β-Carotene in Serum/Plasma

The β-Carotene in Serum/Plasma – HPLC kit is designed for the precise quantification of β-carotene levels in serum and plasma samples. Utilizing a streamlined sample preparation process that combines rapid precipitation and extraction, the kit eliminates the need for evaporation steps, enhancing efficiency.
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Plasma Calibrator Set
3PLUS1 Multilevel Plasma Calibrator Set

The 3PLUS1 Multilevel Plasma Calibrator Set for Antiepileptic Drugs/EXTENDED is a lyophilized calibrator set designed for the quantitative determination of antiepileptic drugs in serum and plasma using LC-MS/MS. Based on human plasma, it includes three distinct concentration levels plus one blank, ensuring precise calibration across a broad analytical range. The set encompasses a comprehensive panel of antiepileptic drugs, facilitating accurate therapeutic drug monitoring in clinical diagnostics.
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Antibiotics Assay
Antibiotics in Serum/Plasma – HPLC

Chromsystems’ Antibiotics in Serum/Plasma is an in vitro diagnostic assay for the quantitative determination of ampicillin, cefepime, ceftazidime, linezolid, meropenem and piperacillin in human serum and plasma samples for monitoring patients’ blood levels of these antibiotics. The HPLC determination with subsequent UV detection is done in two groups, the first run via a mobile phase gradient, the second run isocratically. Two internal standards and stable matrix products ensure precise quantification while the additionally included priming solution increases sample stability notably.
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Cortisol/Cortisone Saliva Controls
MassCheck Chromsystems Saliva Controls

The MassCheck Chromsystems Saliva Controls are intended to monitor the accuracy and precision of each analytical sequence and are available in two different concentration levels. The lyophilized controls are based on human saliva. After reconstitution, they are handled in the same manner as a patient sample and are analyzed under routine conditions analogous to the respective test procedure.
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Data Mining Software
CSQUANT

CSQUANT software helps to simplify and accelerate the evaluation of the data generated by Chromsystems assays – from batch generation through data mining to reporting. CSQUANT can double the speed of complex LC-MS/MS data analysis by gathering the complete LC-MS/MS data and creating the required overviews while providing support through a concise flagging system.
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Sample Concentrator
Sample Concentrator for 96 Well Plates

The Chromsystems Sample Concentrator for 96 Well Plates accelerates the concentration of large sample numbers in mere minutes as compared to traditional methods which normally take hours. The light and compact unit for easy use in fume cupboards ensures fast evaporation of solvents and is ideal for clinical diagnostic purposes, such as Chromsystems MassChrom® Steroids assays.
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Valve Actuator
CLC 230

The CLC 230 valve actuator is suitable as a switching valve for HPLC and LC-MS/MS and is available with an additional column switching valve for up to 6 columns. The CLC 230 valve actuator is ideal for online sample preparation.
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UV-VIS Detector
CLC 420

The CLC 420 is a highly sensitive single-channel UV-VIS detector without any moving mechanical parts and offers the option of wavelength adjustment. The CLC 420 UV-VIS detector is well-suited for clinical routine analysis.
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Hemoglobin Variants Assay
Hemoglobin Variants – HPLC

The Chromsystems assay for the analysis of hemoglobin variants can determine the most common variants HbA1c, HbA2, HbC, HbD, HbE, HbF, and HbS within 9 minutes. A column material specially designed for this specific separation process also allows a stable separation of HbA2 from HbD and HbE even with aged columns. This helps to eliminate false quantifications and qualifications.
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HPLC Column Thermostat Chromsystem
CLC 360

The CLC 360 HPLC Column Thermostat Chromsystem features a temperature controller for stable column temperatures along with an active heating/cooling system and Peltier technology. It also features a highly sensitive leak sensor that detects vapors of organic solvents along with overheat protection.
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HPLC Pump Chromsystem
CLC 320

The CLC 320 HPLC Pump Chromsystem has a high flow rate consistency, low pulsation, and a smaller volume vacuum degasser requiring only 500 μl. It offers a reliable flow with all common mobile phases, making it ideal for routine clinical diagnostic use.
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Drugs of Abuse Testing
MassTox Drugs of Abuse Testing

MassTox Drugs of Abuse Testing is an LC-MS/MS-based assay that helps to increase the speed of analysis and eliminates the need for developing and maintaining in-house methods or specific QC materials. The test is available with reaction vials or 96 well plates and allows the target screening of 108 drugs and metabolites while the confirmatory analysis can also be performed within the same run.
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Neuroleptics Analysis Test
Parameter Set Neuroleptics 1/EXTENDED - LC-MS/MS

This assay enables the quantitative determination of aripiprazole, dehydroaripiprazole, clozapine, desmethylclozapine, haloperidol, quetiapine, norquetiapine, risperidone and 9-OH-risperidone in human serum or plasma samples as well as olanzapine and N-desmethylolanzapine in human EDTA plasma samples via liquid chromatography mass spectrometry (LC-MS/MS). It is intended as a therapeutic drug monitoring test, medically indicated for patients treated with one or more of the neuroleptic drugs listed above.
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Vitamin B1/B6 Test
Vitamin B1 in Whole Blood and Vitamin B6 in Whole Blood / Plasma

This assay enables the quantitative determination of the physiologically active forms of vitamin B1, thiamine pyrophosphate, in human whole blood samples and of vitamin B6, pyridoxal 5‘-phosphate, in human whole blood or plasma samples. It is intended to be used for screening and/or monitoring of vitamin B1 and/or B6 levels.
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Quantitative Amino Acid Analysis Assay
MassChrom® Amino Acid Analysis in Urine with Reaction Vials - LC-MS/MS

This assay enables the quantitative determination of 53 amino acids and metabolites in urine including the parameter creatinine, so that the results can be directly related to the creatinine value without further analysis. It is intended to be used for patients with suspected metabolic diseases in whom the urinary amino acid and metabolic product levels are of clinical importance.
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Immunosuppressant Kit
MassTox® Immunosuppressants in Whole Blood – LC-MS/MS

This assay allows the quantitative determination of cyclosporin A, everolimus, sirolimus (rapamycin), and tacrolimus (FK-506) in human EDTA whole blood samples via liquid chromatography-mass spectrometry (LC-MS/MS). It is intended as a therapeutic drug monitoring test for patients treated with one or several immunosuppressants named above.
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HPLC Gradient Pump
Q-CLC 340

The Q-CLC 340 HPLC Gradient Pump offers a reliable flow with all common mobile phases, making it ideally suited for routine clinical diagnostic use. It offers a consistently high flow rate, low pulsation, and a smaller volume vacuum degasser requiring only 500 μl.
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Newborn Screening Assay
MassChrom Amino Acids and Acylcarnitines from Dried Blood

This Chromsystems assay allows for the fast determination of amino acids and acylcarnitines from dried blood spot samples as part of the newborn screening for amino acid and fatty acid metabolic disorders using tandem mass spectrometry. Sample preparation is based on the effective extraction of the analytes from the blood spot with subsequent derivatization.
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Free Metanephrine Assay
MassChrom Free Metanephrines in Plasma with 96 SPE Well Plate

This assay allows for the quantitative determination of free metanephrine, free normetanephrine and free 3-methoxytyramine in human plasma samples by LC-MS/MS. The assay can be employed as an aid to diagnose and monitor suspected pheochromocytoma or paraganglioma. Furthermore, the assay is an aid to diagnosing and monitoring suspected neuroblastoma.
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25-OH-Vitamin D3/D2 Assay
MassChrom 25-OH-Vitamin D3/D2 in Serum/Plasma - LC-MS/MS

This assay allows the quantitative determination of 25-hydroxycholecalciferol (25-OH-vitamin D3) and 25-hydroxyergocalciferol (25-OH-vitamin D2) in human plasma or serum samples. It is intended to be used for screening and/or monitoring of 25-OH-vitamin D3/D2 levels and further intended to be used as an aid to diagnosis of diseases for which determination of vitamin D levels is indicated.
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Porphyrins Urine Test
Porphyrins in Urine – HPLC

This assay allows for the quantitative determination of uroporphyrin, heptacarboxyporphyrin, hexacarboxyporphyrin, pentacarboxyporphyrin, coproporphyrin I and coproporphyrin III in human urine samples. It is intended to be used primarily as an aid to diagnosis of suspected acute intermittent porphyria, porphyria variegata, aminolevulinic acid dehydratase deficiency porphyria, hereditary coproporphyria, porphyria cutanea tarda or congenital erythropoietic porphyria and/or for their differential diagnosis.
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Homocysteine Test
Homocysteine in Serum/Plasma – HPLC

This Chromsystems assay allows for the simple and reliable determination of total homocysteine in serum/plasma. Sample preparation is simply a reduction step for releasing homocysteine from its protein binding, followed by precipitation and subsequent precolumn derivatization. Chromatographic separation is performed on an isocratic HPLC system with fluorescence detection. The optimized reagents ensure the accurate and reliable quantification of total homocysteine for all blood collection systems within a brief analysis period of less than six minutes.
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β-Thalassaemia Test
β-Thalassemia Testing – HPLC

The Chromsystems assay for β-thalassaemia testing allows the reliable quantification of HbA2 and HbF. The column’s high separation capability allows the determination of the most common variants HbA1c, HbA2, HbC, HbF and HbS in less than six minutes. A column material specially designed for this specific separation process allows a stabilized separation of HbA2 from the other Hb-molecules even with aged columns, helping to avoid misinterpretations and eliminate false quantifications and qualifications.
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Chromsystem
Q-CLC 340

The Q-CLC 340 is an HPLC pump chromsystem with high flow rate consistency, low pulsation and a smaller volume vacuum degasser, requiring only 500 μl. Its pump head drive is permanently lubricated as well as accessible, while its reliable flow with all common mobile phases makes it ideally suited for routine clinical diagnostic use.
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Chromsystem
CLC 100

The CLC 100 is an electrochemical detector chromsystem for the selective detection of oxidisable and reducible substances in medical diagnostics and pharmacology. Complete with flow cell and accessories, it offers a short equilibration time and is suitable for narrow-bore columns.
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Autosampler
CLC 220

The CLC 220 is a fully automated programmable autosampler for variable volume injection with reproducibility and linearity properties. It has a capacity of up to 120 samples for injection into the HPLC system and allows varied injection volumes, while reducing the risk of blockage.
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